Cell-based therapy in prophylaxis and treatment of chronic graft-versus-host disease

Cell-based therapy in prophylaxis and treatment of chronic graft-versus-host disease

Blog Article

Hematopoietic allogeneic stem cell transplantation (allo-SCT) is a Contoured Saddle Pad 30x30 curative option for patients with hematological malignancies.However, due to disparities in major and minor histocompatibility antigens between donor and recipient, severe inflammatory complications can occur, among which chronic graft-versus-host disease (cGVHD) can be life-threatening.A classical therapeutic approach to the prevention and treatment of cGVHD has been broad immunosuppression, but more recently adjuvant immunotherapies have been tested.

This review summarizes and discusses immunomodulatory approaches with T cells, including chimeric antigen receptor (CAR) and regulatory T cells, with natural killer (NK) cells Fridge Water Hose Tap Connector and innate lymphoid cells (ILCs), and finally with mesenchymal stromal cells (MSC) and extracellular vesicles thereof.Clinical studies and pre-clinical research results are presented likewise.